Read e-book online Advances in Immunology, Vol. 16 PDF

By F.J. Dixon, Henry G. Kunkel (Eds.)

ISBN-10: 012022416X

ISBN-13: 9780120224166

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Extra resources for Advances in Immunology, Vol. 16

Example text

Thus, by comparing the activities of Fab, pFc’, Fc, and Facb, it is possible to localize various biological activities and antigenic specificities to each of the threc homology regions. :NT OF V. \ l tl OUS ANTICKNSTO I>IFFEItENT FIL~CMENTS OF IMMUNOGLOBULIN G Antigeri* Inimriiioglobriliri fragrneiits y2-3 71-23 I g ( 2 iirisplit F(ab')? 12 The 72-3 is located i n Fc oritaide pFc' and thus resides in CH2; yl-2-3 is in the ~ F c ' region and thus in CH3; tmd y 2k Fab is in the constant portion of Fd and thus in CHI.

1970a,b) (Fig. 3). Therc arc also subfragments of pFc’. By further digestion with trypsin about 7 N-tcrminal residues are lost, but the tryptic fragment still extends to the C-terminal cncl. This fragment has a slightly faster electrophoretic mobility than pFc’, although it contains all the same genetic antigens as found in pFc’. Finally, by papain digestion, an Fc’ fragment that lacks 8-9 N-terminal residues but also 13 or 14 Cterminal residues as compared to pFc’ (Figs. 4 and 5 ) can be obtained.

Immunoelectroplloresis of pFc' fragnients from each of the four I& subclasses. 2, and IgC3 pFc' fragments, but IgG4 pFc' has a faster mobility. ) Papain I Fc fragment Lys Ile ) pFc' fragment (334 336 Trypsin 4 tFc' fragment + fh y motr y psin ( I336 le A 339) h Papain ( kg) ctFc' fragment Papain Fc' fragment - N-terminus C-terminus - Frc. 5. Schelnatic illustration o f different subfragments of Fc and their probable molecular localization. The numbering corresponds to that of the Eu protein. Residue 446 is the C-tenninal residue.

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Advances in Immunology, Vol. 16 by F.J. Dixon, Henry G. Kunkel (Eds.)

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